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99% Purity Pharmaceutical Grade Prilocaine Powder CAS 721-50-6 For Pain Killer

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99% Purity Pharmaceutical Grade Prilocaine Powder CAS 721-50-6 For Pain Killer

Brand Name : Nanjian
Model Number : 721-50-6
Certification : ISO9001
Place of Origin : China
MOQ : 10g
Price : 1$
Payment Terms : Western Union, MoneyGram, T/T,Bitcoin, L/C
Supply Ability : 100000KG per Week
Delivery Time : 2-7 days
Packaging Details : Disguised
MF : C13H20N2O
MW : 220.31
EINECS : 211-957-0
Mol File : 721-50-6.mol
CAS : 721-50-6
Appearance : White Powder
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Product Description
Prilocaine


Basic information:

Product Name: Prilocaine
Synonyms: 2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512
CAS: 721-50-6
MF: C13H20N2O
MW: 220.31
EINECS: 211-957-0
Product Categories: Active Pharmaceutical Ingredients;Inhibitors
Mol File: 721-50-6.mol
Local Anesthesia Prilocaine Powder 721-50-6 to Numb Tissues
Chemical Properties:

It is a kind of needle-like crystals with the melting point being 37-38 ºC and the boiling point being 159-162 ºC (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ºC. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.

COA :


TestsSpecificationsResults
DescriptionWhite or off-white crystalline powderComplies
Melting rangeBetween 36°C and 39°C36-38°C
Individual impurityNot more than 0.2%Complies
Residue on ignitionNot more than 0.1%0.08%
WaterNot more than 0.5%0.25%
Residual
Solvents
EthanolNot more than 0.05%Not detected
Methylene DichlorideNot more than 0.6%Not detected
Assay (%)99.0%~101.0%99.54%
Conclusion: Conforms to USP34

Application:

Application It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.


Usage And Synthesis:

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.


Pharmacological

Its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6 ~ 7min and the duration time of about 1.5 ~ 2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta.


Adverse reactions

once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring.

Note

patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia.

Usage and dosage:
infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5% ~ 1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.


Product Tags:

local anesthesia drugs

      

topical anesthetic drugs

      
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