Hydrochlorothiazide Pharmaceutical Raw Materials CAS 58-93-5 BP
|Product Name:||Hydrochlorothiazides intermediate|
|Product Categories:||Losartan Potassium & raw Hydrochlorothiazides
Compounds;Heterocycles;Inhibitors;Ion transporter and other ion
channel;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur
& Selenium Compounds;API;ESIDRIX;Other APIs|
The product is a typical representative in the thiazide diuretic
drug with its pharmaceutical sales in United States ranking first
in 1985. Owing to its easy administration, moderate action as well
as being suitable for all kinds of edema, it is most often
clinically applied. Owing to adverse reactions like potassium
secretion, we should pay attention to supplement potassium salt
during the application. Intravenous injection-mice-LD50: 590mg /
kg, oral LD50: greater than 8000mg / kg.
It mainly inhibits the re-absorption on Na+ and Cl- by the proximal
end of the distal convoluted tubule so that renal excretion of
sodium chloride is increased to produce a diuretic effect. It is a
kind of diuretic drugs of moderate effect. This product has
antihypertensive effect with the effect being enhanced when being
use in combination with Lee medicine paste, antihypertensive shen
paste or apocynum venetum and other traditional Chinese medicine.
This product also has anti-diuretic effect and can be used for the
treatment of diabetes insipidus
Oral ordinary tablet: the efficacy onset of oral administration is
in 2h with plasma concentration reaching peak at 4 hour and the
effect lasting for 6 ~ 12h.
Adults: (1) for the treatment of edema disease, a 25 ~ 50mg, qd or
bid, or qod; or take drug 3 ~ 5d weekly with a interval of 3 ~ 4d.
(2) For the treatment of hypertension with the dose of 25 to 100 mg
per day and divided into 1-2 times for administration. It needs to
be used in combination with other antihypertensive drugs and should
be subject to dose adjustment according to the actual
antihypertensive effect. The dose is usually reduced to 25 to 50 mg
per day within one week. (3) for the treatment of diabetes
insipidus, take 25mg once tid, or 50 mg once, qd.
Children: treatment of edema disease, take 1 ~ 2mg / kg per day and
divided 1-2 times for administration. Adjust the dose according to
the actual efficacy.
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