CAS 96-48-0 Pharmaceutical Raw Materials GBL / Gamma -
Butyrolactone For Wheel Cleaner
Gamma Butyrolactone Application
Gamma-Butyrolactone is a hygroscopic colorless liquid with a weak characteristic odor
which is soluble in water. is a common solvent and reagent in
chemistry as well as being used as a flavouring, as a cleaning
solvent, as a superglue remover, and as a solvent in some wet
aluminium electrolytic capacitors. In humans it acts as a prodrug
for, and it is used as a recreational intoxicant with effects
similar to alcohol.
Gamma-Butyrolactone has been found in extracts from samples of unadulterated wines.
This finding indicates that Gamma-Butyrolactone is a naturally occurring component in some wines and may be present
in similar products. The concentration detected was approximately 5
μg/mL and was easily observed using a simple extraction technique
followed by GC/MS analysis. Gamma-Butyrolactone can be found in cheese flavourings but typically results in a
content of 0.0002%Gamma-Butyrolactone in the final foodstuff.
Under acidic conditions it forms an equilibrium mixture of both
compounds. These compounds then may go on to form a polymer. When
treated with a non-nucleophilic base, like lithium
diisopropylamide, Gamma-Butyrolactone can become an alpha-carbon nucleophile. The related compound
caprolactone can be used to make a polyester in this manner.
Gamma-Butyrolactone is not active in its own right; its mechanism of action stems from
its identity as a prodrug of .
The hypnotic effect of is enhanced by combination with alcohol. A
2003 rat study showed that Gamma-Butyrolactone in combination with ethanol showed a potentiated hypnotic effect,
as the sleep-timing measure was longer than both of the individual
Gamma-Butyrolactone is rapidly converted into by paraoxonase (lactonase) enzymes, found
in the blood. Animals which lack these enzymes exhibit no effect
from Gamma-Butyrolactone. Gamma-Butyrolactone is more lipophilic (fat soluble) than, and so is absorbed faster
and has higher bioavailability. Because of these pharmacokinetic
differences, Gamma-Butyrolactone tends to be more potent and faster-acting than, but has a shorter
duration; whereas the related compound 1,4-butanediol (1,4-B) tends
to be slightly less potent, slower to take effect but longer-acting
Gamma-Butyrolactone Legal Status
Australia: GBL is not classified as a drug but as a
health-endangering substance. Although recently passed legislation
to enter into force on 1 April 2011 will make it possible to handle
narcotics for industrial purposes will enable GBL and
1,4-Butanediol to be classified as controlled substances.
Canada: GBL is a Controlled Substance under Schedule VI of the
"Controlled Drugs and Substances Act" in Canada. Schedule VI of the
"Controlled Drugs and Substances Act" requires vendors to collect
information regarding purchases of GBL. The Act also prohibits the
import and export of GBL into or out of Canada classifying it as
either an indictable offense punishable with up to 10 years in
prison or an offense punishable on summary conviction liable to
imprisonment for up to eighteen months. It is not illegal for an
individual to possess GBL in Canada.
Germany: GBL is not listed in the narcotics law, but its
distribution is controlled. Possession is not illegl, but may be
punished according to the Medicines Act, when intended to be sold
for human consumption or synthesis of GHB. In recent years, an
increase of GBL consumption has been observed due to the
prohibition of GHB.
United States: GBL is regulated as a List 1 controlled chemical. As
a GHB analog, it is treated as a controlled substance under
Schedule I of the "Controlled Substances Act" if intended for human
Poland: GBL is not classified as a drug and can be purchased in
chemistry shops as a solvent.
Israel: GBL was classified as a proscribed substance from 2007.
Sweden: GBL is not classified as a drug but as a health-endangering
substance. Although recently passed legislation to enter into force
on 1 April 2011 will make it possible to handle narcotics for
industrial purposes will enable GBL and 1,4-Butanediol to be
classified as controlled substances.
United Kingdom: Because of their legitimate uses, regulation 4B of
the 2001 regulations makes it lawful to import, export, produce,
supply, offer to supply or possess GBL and 1,4-BD. Except where a
person does so knowing or believing that they will be used for the
purpose of human ingestion.
Hong Kong SAR: GBL is a dangerous drug controlled under Schedule 1
of the Dangerous Drugs Ordinance, Cap.134 (with exemption clause at
Paragraph 16D). Any person who is found to have in his possession
of it not in accordance with this Ordinance can be liable, on
conviction upon indictment, a fine of HK$1,000,000 and to
imprisonment for 7 years.
The Netherlands: GBL has been placed on list 1 of the "Opiumwet"
(freely translated: "Opiumlaw"). Therefore, export and import,
possession, manufacturing, sale and transport are forbidden.
However, use of drugs forbidden by the Opiumwet is not considered
illegal, but mainly treated as a public health concern.
Russia: GBL is classified as psychotropic substance since 22
February 2012, its traficking is limited, and non-licensed selling,
buying or any other using is imprisoned up to 20 years.
|Appearance||Colorless clear liquid||Colorless clear liquid|
|Purity (wt%, GC)||≥99.80||99.80|
|Moisture (wt%, K.F.)||≤0.03||0.020|
|Glycol (wt%, GC)||≤0.02||0.003|
|Tetrahydrofuran (wt%, GC)||≤0.03||0.024|
Conclusion: It conforms to electron level
Packaging & Delivery
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ship 100 grams to 100kg powders at one time to your country. Fast
and discreet shipment could be arranged for customs pass
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You also can choose your own shipping forwarder.
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usually it takes about 3-5 to reach you; for larger orders, it will
take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you
first for you to confirm the
quality, but if you find our products not confirm with the COA
after you receive it, please show
us your test result, we will refund you once we confirm that.