|Product name||Tetracaine HCl Factory Supplying|
|Other name||Tetracaine hydrochloride|
|CAS register number||136-47-0|
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The
ethyl ester is formed through an acid-catalyzed esterification
reaction. Base-catalyzed transesterification is achieved by boiling
the ethyl ester of 4-butylaminobenzoic acid with excess
2-dimethylaminoethanol in the presence of a small amount of sodium
|Test Items||Specification||Test Results|
|Appearance||Fine, white, crystalline, odorless powder||confirm|
|Identification||ABC in Pass||confirm|
|Solubility||Very soluble in water, soluble in Alcohol;|
insoluble in Ether and Benzene
|USP Reference standards||USP Tetracaine Hydrochloride RS.|
USP Endotoxin RS.
|Melting point||145~150 degree|
|Chromatographic purity||In Pass||confirm|
|Related substance||Not more than the reference solution 0.05%||confirm|
|Residue on ignition||≤0.10%||0.05%|
|Loss on Drying||≤ 0.5%||0.19%|
|Conclusion||Confirms USP 32|
Tetracaine (INN, also known as amethocaine; trade name Pontocaine.
Ametop and Dicaine) is a potent local anesthetic of the ester
group. It is mainly used topically in ophthalmology and as an
antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of
calcium release channels (ryanodine receptors) that control the
release of calcium from intracellular stores. Tetracaine is an
allosteric blocker of channel function. At low concentrations,
tetracaine causes an initial inhibition of spontaneous calcium
release events, while at high concentrations, tetracaine blocks
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